Feasibility and indicative results from a 12-month low-energy liquid diet treatment and maintenance programme for severe obesity

Br J Gen Pract. 2013 Feb;63(607):e115-24. doi: 10.3399/bjgp13X663073.

Abstract

Background: There is no established primary care solution for the rapidly increasing numbers of severely obese people with body mass index (BMI) > 40 kg/m(2).

Aim: This programme aimed to generate weight losses of ≥15 kg at 12 months, within routine primary care.

Design and setting: Feasibility study in primary care.

Method: Patients with a BMI ≥40 kg/m(2) commenced a micronutrient-replete 810-833 kcal/day low-energy liquid diet (LELD), delivered in primary care, for a planned 12 weeks or 20 kg weight loss (whichever was the sooner), with structured food reintroduction and then weight-loss maintenance, with optional orlistat to 12 months.

Result: Of 91 patients (74 females) entering the programme (baseline: weight 131 kg, BMI 48 kg/m(2), age 46 years), 58/91(64%) completed the LELD stage, with a mean duration of 14.4 weeks (standard deviation [SD] = 6.0 weeks), and a mean weight loss of 16.9 kg (SD = 6.0 kg). Four patients commenced weight-loss maintenance omitting the food-reintroduction stage. Of the remaining 54, 37(68%) started and completed food reintroduction over a mean duration of 9.3 weeks (SD = 5.7 weeks), with a further mean weight loss of 2.1 kg (SD = 3.7 kg), before starting a long-term low-fat-diet weight-loss maintenance plan. A total of 44/91 (48%) received orlistat at some stage. At 12 months, weight was recorded for 68/91 (75%) patients, with a mean loss of 12.4 kg (SD = 11.4 kg). Of these, 30 (33% of all 91 patients starting the programme) had a documented maintained weight loss of ≥15 kg at 12 months, six (7%) had a 10-15 kg loss, and 11 (12%) had a 5-10 kg loss. The indicative cost of providing this entire programme for wider implementation would be £861 per patient entered, or £2611 per documented 15 kg loss achieved.

Conclusion: A care package within routine primary care for severe obesity, including LELD, food reintroduction, and weight-loss maintenance, was well accepted and achieved a 12-month-maintained weight loss of ≥15 kg for one-third of all patients entering the programme.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Obesity Agents / therapeutic use
  • Diet, Reducing / methods*
  • Feasibility Studies
  • Feeding Behavior
  • Feeding Methods
  • Female
  • Humans
  • Lactones / therapeutic use
  • Male
  • Micronutrients / administration & dosage
  • Middle Aged
  • Obesity, Morbid / diet therapy*
  • Orlistat
  • Patient Compliance
  • Patient Education as Topic
  • Patient Satisfaction
  • Treatment Outcome
  • Weight Loss
  • Young Adult

Substances

  • Anti-Obesity Agents
  • Lactones
  • Micronutrients
  • Orlistat