Autism, seasonality and the environmental perturbation of epigenome related vitamin levels

Mark Lucock; Robert Leeming

doi:10.1016/j.mehy.2013.03.003

Autism, seasonality and the environmental perturbation of epigenome related vitamin levels

Med Hypotheses. 2013 Jun;80(6):750-5. doi: 10.1016/j.mehy.2013.03.003. Epub 2013 Apr 6.

Authors

Mark Lucock¹, Robert Leeming

Affiliation

¹ Molecular Nutrition Laboratory, School of Environmental and Life Sciences, University of Newcastle, New South Wales, Australia. Mark.Lucock@newcastle.edu.au

PMID: 23566657
DOI: 10.1016/j.mehy.2013.03.003

Abstract

An argument is put forward for environmental modulators of photolabile or photosynthetic vitamins mediating autism risk via a complex downstream interaction of genetic/epigenetic phenomena that provide an explanation for seasonality in this and other developmentally originated disorders.

MeSH terms

Biopterins / adverse effects
Biopterins / analogs & derivatives
Child Development Disorders, Pervasive / etiology*
Female
Folic Acid / metabolism
Humans
Methylenetetrahydrofolate Reductase (NADPH2) / metabolism
Models, Biological*
Pregnancy
Prenatal Exposure Delayed Effects / chemically induced*
Seasons*
Ultraviolet Rays / adverse effects*
Vitamins / radiation effects*
Vitamins / toxicity

Substances

Vitamins
Biopterins
Folic Acid
MTHFR protein, human
Methylenetetrahydrofolate Reductase (NADPH2)
sapropterin