Poor outcome of HIV-infected patients with plasmablastic lymphoma: results from the German AIDS-related lymphoma cohort study

AIDS. 2013 Mar 13;27(5):842-5. doi: 10.1097/QAD.0b013e32835e069d.

Abstract

Out of 302 AIDS-related lymphoma (ARL) patients enrolled in the German ARL cohort study, 18 patients had plasmablastic lymphoma (PBL). Twelve out of 18 patients (67%) have died with a median survival of 4 months (range 0-11 months). In univariate analysis, an intermediate or high international prognostic index score was associated with a significantly lower overall survival and progression-free survival. The predominant cause of death was progressive lymphoma (67%). Our data indicate that the outcome of AIDS-related PBL is still very poor.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Analysis of Variance
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Antiretroviral Therapy, Highly Active / methods*
  • Cohort Studies
  • Germany
  • HIV Infections / complications
  • HIV Infections / drug therapy
  • HIV Infections / mortality*
  • Humans
  • Lymphoma, AIDS-Related / drug therapy
  • Lymphoma, AIDS-Related / etiology
  • Lymphoma, AIDS-Related / mortality*
  • Lymphoma, Non-Hodgkin / drug therapy
  • Lymphoma, Non-Hodgkin / etiology
  • Lymphoma, Non-Hodgkin / mortality*
  • Male
  • Middle Aged
  • Prognosis
  • Prospective Studies
  • Severity of Illness Index