Xpert MTB/RIF testing of stool samples for the diagnosis of pulmonary tuberculosis in children

Clin Infect Dis. 2013 Aug;57(3):e18-21. doi: 10.1093/cid/cit230. Epub 2013 Apr 11.

Abstract

In a pilot accuracy study, stool Xpert testing from 115 children with suspected pulmonary tuberculosis (PTB) detected 8/17 (47%) culture-confirmed tuberculosis cases, including 4/5 (80%) HIV-infected and 4/12 (33%) HIV-uninfected children. Sputum Xpert detected 11/17 (65%) cases. Stool holds promise for PTB diagnosis in HIV-infected children.

Keywords: Xpert; children; diagnosis; stool; tuberculosis.

Publication types

  • Evaluation Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Bacteriological Techniques / methods*
  • Child
  • Child, Preschool
  • Feces / microbiology*
  • Female
  • Humans
  • Infant
  • Male
  • Molecular Diagnostic Techniques / methods*
  • Mycobacterium tuberculosis / isolation & purification*
  • Pilot Projects
  • Prospective Studies
  • Tuberculosis, Pulmonary / diagnosis*