Fatal adenovirus encephalomyeloradiculitis in an umbilical cord stem cell transplant recipient

Neurology. 2013 Apr 30;80(18):1715-7. doi: 10.1212/WNL.0b013e3182904f96. Epub 2013 Apr 17.

Abstract

Adenovirus infections frequently complicate allogeneic stem cell transplants but nervous system involvement, usually presenting as encephalitis, is atypical. Progression from encephalitis to myeloradiculitis has not been described previously.1 We present a unique case of fatal adenoviral encephalomyeloradiculitis with imaging and pathologic correlates.

Publication types

  • Case Reports

MeSH terms

  • Adenoviridae Infections / drug therapy*
  • Adenoviridae Infections / etiology
  • Antiviral Agents / therapeutic use
  • Cidofovir
  • Cord Blood Stem Cell Transplantation / adverse effects*
  • Cytosine / analogs & derivatives*
  • Cytosine / therapeutic use
  • Encephalomyelitis / drug therapy*
  • Encephalomyelitis / etiology
  • Fatal Outcome
  • Female
  • Humans
  • Leukemia, Prolymphocytic, T-Cell / therapy*
  • Middle Aged
  • Organophosphonates / therapeutic use*

Substances

  • Antiviral Agents
  • Organophosphonates
  • brincidofovir
  • Cytosine
  • Cidofovir