Perspectives in targeting miRNA function

Abstract

First oligonucleotide analogues that inhibit miRNA function are currently investigated in clinical trials. In addition, several alternative methods are under development that may allow for controlling miRNA function by small molecules-mediated inhibiting of its biogenesis. In this perspectives article, we provide a short overview on recent developments in this field.

Keywords: Antagomirs; High throughput screening; Small molecules; miRNA.