In vitro biodegradation experiments were done using some probiotic microorganisms. DifferentSaccharomyces cerevisiae, Lactobacilli andBacilli strains were tested for their ability to degrade Nivalenol (NIV), Deoxynivalenol (DON), Diacetoxyscirpenol (DAS), T2-Toxin and Ochratoxin A (OTA). The concentrations of selected mycotoxins were in the range of natural occurring toxin contaminations (1ppm for NIV and DON, 500ppb for DAS and T-2 and 50ppb for OTA). No alteration of concentrations could be registered for the tested trichothecenes. The best results could be achieved in experiments with OTA by up to 94% detoxification. Influence of toxins on colony forming unit of all tested microorganisms were recorded. Especially T-2 toxin and DAS have a slowing effect on growth of some strains.