Fiber connectivity between the striatum and cortical and subcortical regions is associated with temperaments in Chinese males

Xuemei Lei; Chuansheng Chen; Feng Xue; Qinghua He; Chunhui Chen; Qi Liu; Robert K Moyzis; Gui Xue; Zhongyu Cao; Jin Li; He Li; Bi Zhu; Yuyun Liu; Anna Shan Chun Hsu; Jun Li; Qi Dong

doi:10.1016/j.neuroimage.2013.04.043

Fiber connectivity between the striatum and cortical and subcortical regions is associated with temperaments in Chinese males

Neuroimage. 2014 Apr 1:89:226-34. doi: 10.1016/j.neuroimage.2013.04.043. Epub 2013 Apr 22.

Authors

Xuemei Lei¹, Chuansheng Chen², Feng Xue³, Qinghua He⁴, Chunhui Chen³, Qi Liu³, Robert K Moyzis⁵, Gui Xue⁶, Zhongyu Cao³, Jin Li³, He Li³, Bi Zhu³, Yuyun Liu³, Anna Shan Chun Hsu⁷, Jun Li³, Qi Dong⁸

Affiliations

¹ State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China; Department of Psychology and Social Behavior, University of California, Irvine, CA, USA.
² Department of Psychology and Social Behavior, University of California, Irvine, CA, USA. Electronic address: Chuansheng.Chen@uci.edu.
³ State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
⁴ Institute of Genomics and Bioinformatics, University of California, Irvine, CA, USA.
⁵ Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA; Institute of Genomics and Bioinformatics, University of California, Irvine, CA, USA.
⁶ State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China; Department of Psychology, University of Southern California, Los Angeles, CA 90089, USA.
⁷ Department of Psychology and Social Behavior, University of California, Irvine, CA, USA.
⁸ State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China. Electronic address: dongqi@bnu.edu.cn.

PMID: 23618602
DOI: 10.1016/j.neuroimage.2013.04.043

Abstract

The seven-factor biopsychosocial model of personality distinguished four biologically based temperaments and three psychosocially based characters. Previous studies have suggested that the four temperaments-novelty seeking (NS), reward dependence (RD), harm avoidance (HA), and persistence (P)-have their respective neurobiological correlates, especially in the striatum-connected subcortical and cortical networks. However, few studies have investigated their neurobiological basis in the form of fiber connectivity between brain regions. This study correlated temperaments with fiber connectivity between the striatum and subcortical and cortical hub regions in a sample of 50 Chinese adult males. Generally consistent with our hypotheses, results showed that: (1) NS was positively correlated with fiber connectivity from the medial and lateral orbitofrontal cortex (mOFC, lOFC) and amygdala to the striatum; (2) RD was positively correlated with fiber connectivity from the mOFC, posterior cingulate cortex/retrosplenial cortex (PCC), hippocampus, and amygdala to the striatum; (3) HA was positively linked to fiber connectivity from the dorsolateral prefrontal cortex (dlPFC) and PCC to the striatum; and (4) P was positively linked to fiber connectivity from the mOFC to the striatum. These results extended the research on the neurobiological basis of temperaments by identifying their anatomical fiber connectivity correlates within the subcortical-cortical neural networks.

Keywords: DTI; Diffusion tensor imaging; Personality; Striatum; TCI; Temperaments.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Amygdala / anatomy & histology
Asian People
Brain / anatomy & histology*
Cerebral Cortex / anatomy & histology*
Corpus Striatum / anatomy & histology*
Diffusion Tensor Imaging
Humans
Male
Nerve Fibers, Myelinated
Nerve Net / anatomy & histology*
Neural Pathways
Temperament*
Young Adult