Reports of patients and relatives from the CogniCIS study about cognition in clinically isolated syndrome: what are our patients telling us?

D W Langdon; R H B Benedict; E M Wicklein; K Beckmann; S Fredrikson

doi:10.1159/000345698

Reports of patients and relatives from the CogniCIS study about cognition in clinically isolated syndrome: what are our patients telling us?

Eur Neurol. 2013;69(6):346-51. doi: 10.1159/000345698. Epub 2013 Apr 26.

Authors

D W Langdon¹, R H B Benedict, E M Wicklein, K Beckmann, S Fredrikson

Affiliation

¹ Royal Holloway, University of London, London, UK. d.langdon@rhul.ac.uk

PMID: 23635720
DOI: 10.1159/000345698

Abstract

Objective: To assess the Multiple Sclerosis Neuropsychological Questionnaire (MSNQ) in patients with clinically isolated syndrome (CIS).

Methods: 130 European CIS patients and 60 relatives completed the MSNQ.

Results: The mean (SD) MSNQ score for CIS patients was 15.5 (10.8) and for their informants 11.3 (9.6). Neither the CIS patient nor relative MSNQ report scores correlated with any of the cognitive test scores in the Brief Repeatable Battery of Neuropsychological Tests, but they were significantly related to psychosocial scales including depression.

Conclusions: In CIS, patient and relative MSNQ scores are influenced by psychosocial variables rather than actual objective cognitive status. Formal cognitive test assessment is recommended for CIS patients.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cognition*
Demyelinating Diseases / psychology*
Female
Humans
Male
Neuropsychological Tests
Psychology