Effects of specific antibodies and immunocompetent cells on tumor growth in passive transfer experiment

A V Zhigunova; E G Kravtsov; N V Yashina; M V Dalin; L P Karpenko

doi:10.1007/s10517-013-2050-3

Effects of specific antibodies and immunocompetent cells on tumor growth in passive transfer experiment

Bull Exp Biol Med. 2013 Apr;154(6):762-4. doi: 10.1007/s10517-013-2050-3.

Authors

A V Zhigunova¹, E G Kravtsov, N V Yashina, M V Dalin, L P Karpenko

Affiliation

¹ Department of Microbiology and Virology, Russian University of Peoples' Friendship, Moscow, Russia. zhigunova2003@mail.ru

PMID: 23658918
DOI: 10.1007/s10517-013-2050-3

Abstract

Experiments with passive transfer of immunocompetent cell and serum demonstrated suppression of tumor growth after transfer of splenocytes from animals immunized with Trypanosoma cruzi. The nonspecific constituent of antitumor effect of immunocompetent cells was detected. The previously reported oncoprotective effect of mucins 2 and 3 was not confirmed.

MeSH terms

Animals
Antibodies, Protozoan / immunology*
Carcinoma, Ehrlich Tumor / immunology
Carcinoma, Ehrlich Tumor / pathology
Carcinoma, Ehrlich Tumor / therapy*
Cell Transplantation*
Female
Immunization
Mice
Mice, Inbred BALB C
Mucins / immunology
Neoplasm Transplantation
Protozoan Proteins / immunology
Spleen / cytology*
Spleen / immunology
Trypanosoma cruzi / immunology*
Tumor Burden

Substances

Antibodies, Protozoan
Mucins
Protozoan Proteins