Synephrine-containing dietary supplement precipitating apical ballooning syndrome in a young female

Korean J Intern Med. 2013 May;28(3):356-60. doi: 10.3904/kjim.2013.28.3.356. Epub 2013 May 1.

Abstract

Apical ballooning syndrome (ABS) is a unique reversible cardiomyopathy that is frequently precipitated by emotional or physical stress. In addition, the few drugs reported to precipitate ABS were either illegal or strictly controlled for medical use. This paper reports a case of ABS precipitated by a dietary supplement. Our case accentuates the potential risk of dietary supplements containing synephrine, which is uncontrolled and available to the general public. Therefore, the Korea Food and Drug Administration should regulate these dietary supplements, and warn healthcare workers and the general public of the potential hazards of the indiscriminate abuse of dietary supplements.

Keywords: Dietary supplements; Synephrine; Takotsubo cardiomyopathy.

Publication types

  • Case Reports

MeSH terms

  • Adrenergic alpha-Agonists / adverse effects*
  • Dietary Supplements / adverse effects
  • Female
  • Humans
  • Synephrine / adverse effects*
  • Takotsubo Cardiomyopathy / chemically induced*
  • Young Adult

Substances

  • Adrenergic alpha-Agonists
  • Synephrine