The dynamics of HCF-1 modulation of herpes simplex virus chromatin during initiation of infection

Jodi L Vogel; Thomas M Kristie

doi:10.3390/v5051272

The dynamics of HCF-1 modulation of herpes simplex virus chromatin during initiation of infection

Viruses. 2013 May 22;5(5):1272-91. doi: 10.3390/v5051272.

Authors

Jodi L Vogel¹, Thomas M Kristie

Affiliation

¹ National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bld. 33, 33 North Drive, Bethesda, MD 20892, USA. jvogel@niaid.nih.gov

Abstract

Successful infection of herpes simplex virus is dependent upon chromatin modulation by the cellular coactivator host cell factor-1 (HCF-1). This review focuses on the multiple chromatin modulation components associated with HCF-1 and the chromatin-related dynamics mediated by this coactivator that lead to the initiation of herpes simplex virus (HSV) immediate early gene expression.

Publication types

Research Support, N.I.H., Intramural
Review

MeSH terms

Chromatin / metabolism*
Gene Expression Regulation, Viral
Host Cell Factor C1 / metabolism*
Host-Pathogen Interactions*
Humans
Simplexvirus / physiology*
Virus Replication*

Substances

Chromatin
HCFC1 protein, human
Host Cell Factor C1

Grants and funding

Intramural NIH HHS/United States