Glucosamine alleviates scopolamine induced spatial learning and memory deficits in rats

Khadijeh Jamialahmadi; Hamid Reza Sadeghnia; Ghazaleh Mohammadi; Ali Masoudi Kazemabad; Mahmoud Hosseini

doi:10.1016/j.pathophys.2013.04.003

Glucosamine alleviates scopolamine induced spatial learning and memory deficits in rats

Pathophysiology. 2013 Sep;20(4):263-7. doi: 10.1016/j.pathophys.2013.04.003. Epub 2013 Jun 2.

Authors

Khadijeh Jamialahmadi¹, Hamid Reza Sadeghnia, Ghazaleh Mohammadi, Ali Masoudi Kazemabad, Mahmoud Hosseini

Affiliation

¹ Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

PMID: 23735432
DOI: 10.1016/j.pathophys.2013.04.003

Abstract

Introduction and objective: Beneficial effects of glucosamine in spatial learning and memory impairment induced by scopolamine has been evaluated in rats by using Morris water maze.

Methods: Male Wistar rats were randomly divided into control, scopolamine and scopolamine plus glucosamine groups. All injections were given in 5 consecutive days and 30min after each injection, the rats were tested in the Morris water maze test. Escape latency and path length to reach the hidden platform were subjected to analysis of variance [ANOVA].

Results: The rats treated with scopolamine showed increased escape latency and path length to reach the hidden platform compared to control group (P<0.001). Both escape latency and traveled path length to reach the hidden platform in glucosamine treated animals (1 and 2g/kg) were significantly lower (P<0.05 to P<0.001) than in the scopolamine group.

Conclusion: The results of this study showed that the glucosamine can inhibit scopolamine-induced impairments of spatial learning and memory in rats. Glucosamine might offer a promise in either the prevention or the treatment of neurodegenerative diseases such as Alzheimer's disease.

Keywords: Male rats; Morris water maze; Scopolamine; Spatial learning and memory; d-Glucosamine.