Neonatal transfusion-transmitted hepatitis C virus infection following a pre-seroconversion window-phase donation in Sweden

Jesper Waldenström; Jan Konar; Bengt Ekermo; Helene Norder; Martin Lagging

doi:10.3109/00365548.2013.797601

Neonatal transfusion-transmitted hepatitis C virus infection following a pre-seroconversion window-phase donation in Sweden

Scand J Infect Dis. 2013 Oct;45(10):796-9. doi: 10.3109/00365548.2013.797601. Epub 2013 Jun 9.

Authors

Jesper Waldenström¹, Jan Konar, Bengt Ekermo, Helene Norder, Martin Lagging

Affiliation

¹ From the Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg.

PMID: 23746339
DOI: 10.3109/00365548.2013.797601

Abstract

A 9-day-old child developed a transfusion-transmitted hepatitis C virus (HCV) infection following a pre-seroconversion window-phase donation. Retrospective analysis of donor plasma revealed detectable HCV core antigen (154 fmol/l), as well as HCV RNA (87,000 IU/ml). Of 5.24 million Swedish plasma samples from December 1998 to September 2012, 5 additional window-phase donations were identified.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Hepatitis C / diagnosis*
Hepatitis C / transmission*
Hepatitis C Antigens / blood
Humans
Infant, Newborn
Male
Plasma / virology
RNA, Viral / blood
Sweden
Transfusion Reaction*
Viral Core Proteins / blood

Substances

Hepatitis C Antigens
RNA, Viral
Viral Core Proteins
core protein p22, Hepatitis C virus