Continuous infusion meropenem and ticarcillin-clavulanate in pediatric cystic fibrosis patients

Abstract

Aztreonam, cefepime, and ceftazidime are anti-pseudomonal beta-lactam antibiotics which have been previously reported to be administered by continuous infusion (CI) in pediatric CF patients. We present two cases administering intravenous (IV) meropenem and ticarcillin-clavulanate by CI in pediatric CF patients. The delivery of beta-lactam antibiotics via CI should be considered in order to optimize the pharmacodynamics (PD) of beta-lactams in the treatment of acute pulmonary exacerbations (APE).

Keywords: Inquilinus limosus; Pseudomonas aeruginosa; antibiotics; beta-lactams.