Mutagenic assessment of three synthetic pyridine-diaryl ketone derivatives

Toxicol Ind Health. 2015 Dec;31(12):1252-7. doi: 10.1177/0748233713491810. Epub 2013 Jun 20.

Abstract

Nowadays, there are increasing numbers of studies about synthetic chemicals according to the supply demands of bioactive chemicals. The current study aims to investigate genotoxic potential of bioactive synthetic pyridine compounds, phenyl-3-pyridinylmethanone (1), p-tolyl-3-pyridinylmethanone (2), and 4-methoxyphenyl-3-pyridinylmethanone (3), using Ames/Salmonella and Escherichia coli WP2 bacterial reversion mutagenicity test systems. The mutant bacterial tester strains sodium azide-sensitive Salmonella typhimurium TA1535, 9-aminoacridine-sensitive S. typhimurium TA1537, and N-methyl-N'-nitro-N-nitrosoguanidine-sensitive E. coli WP2uvrA were used to detect the mutagenic potential of the test compounds. The results indicated that none of the test substances showed significant mutagenic activity on S. typhimurium TA1535, TA1537, and E. coli WP2uvrA bacterial strains up to 1 µg/plate concentrations.

Keywords: Ames/Salmonella; E. coli WP2; Mutagenicity; synthetic pyridine compounds.

MeSH terms

  • Escherichia coli / drug effects
  • Escherichia coli / genetics
  • Escherichia coli / growth & development
  • Escherichia coli / metabolism
  • Ketones / toxicity*
  • Microbial Viability / drug effects
  • Mutagenesis / drug effects*
  • Mutagenicity Tests
  • Mutagens / toxicity*
  • Osmolar Concentration
  • Pyridines / toxicity*
  • Salmonella typhimurium / drug effects
  • Salmonella typhimurium / genetics
  • Salmonella typhimurium / growth & development
  • Salmonella typhimurium / metabolism
  • Solvents / toxicity*
  • Turkey

Substances

  • 4-methoxyphenyl-3-pyridinylmethanone
  • Ketones
  • Mutagens
  • Pyridines
  • Solvents
  • p-tolyl-3-pyridinylmethanone
  • phenyl-3-pyridinylmethanone