Iodine-131 metaiodobenzylguanidine (I-131 MIBG) diagnosis and therapy of pheochromocytoma and paraganglioma: current problems, critical issues and presentation of a sample case

Q J Nucl Med Mol Imaging. 2013 Jun;57(2):146-52.

Abstract

Iodine-131 metaiodobenzylguanidine (I-131 MIBG) has been used for the diagnosis and treatment of malignant pheochromocytomas (PHEO) and paragangliomas (PGL) since 1980's. Despite increasing amount of experience with iodine-131 (I-131) MIBG therapy, many important questions still exist. In this article, we will discuss the current problems learned from clinical experience in diagnosis and therapy of PHEO/PGL with I-131 MIBG, and present a sample case to emphasize the critical aspects for an optimal treatment strategy.

Publication types

  • Case Reports
  • Meta-Analysis
  • Review

MeSH terms

  • 3-Iodobenzylguanidine / therapeutic use*
  • Adrenal Gland Neoplasms / diagnostic imaging*
  • Adrenal Gland Neoplasms / radiotherapy*
  • Humans
  • Image Enhancement / methods*
  • Male
  • Middle Aged
  • Paraganglioma / diagnostic imaging*
  • Paraganglioma / radiotherapy*
  • Radionuclide Imaging
  • Radiopharmaceuticals / therapeutic use
  • Treatment Outcome

Substances

  • Radiopharmaceuticals
  • 3-Iodobenzylguanidine