Adaptation of molecular circadian clockwork to environmental changes: a role for alternative splicing and miRNAs

Proc Biol Sci. 2013 Jul 3;280(1765):20130011. doi: 10.1098/rspb.2013.0011. Print 2013 Aug 22.

Abstract

Circadian (24 h) clocks provide a source of internal timing in most living organisms. These clocks keep time by using complex transcriptional/post-translational feedback loops that are strikingly resilient to changes in environmental conditions. In the last few years, interest has increased in the role of post-transcriptional regulation of circadian clock components. Post-transcriptional control plays a prominent role in modulating rapid responses of the circadian system to environmental changes, including light, temperature and general stress and will be the focus of this review.

Keywords: circadian clock; environment; post-transcriptional regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alternative Splicing*
  • Animals
  • Arabidopsis / genetics
  • Arabidopsis / metabolism
  • Arabidopsis / physiology
  • Circadian Clocks / genetics*
  • Circadian Clocks / physiology
  • Circadian Rhythm / genetics
  • Circadian Rhythm / physiology
  • Drosophila melanogaster / genetics
  • Drosophila melanogaster / physiology
  • Humans
  • Mice
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Neurospora / genetics
  • Neurospora / metabolism
  • Protein Processing, Post-Translational*

Substances

  • MicroRNAs