A cross-sectional assessment of oxidative DNA damage and muscle strength among elderly people living in the community

Environ Health Prev Med. 2014 Jan;19(1):21-9. doi: 10.1007/s12199-013-0350-x. Epub 2013 Jul 19.

Abstract

Objectives: The mechanism by which muscle weakness leads to an increased risk of death remains a subject of interest. In this context, the aim of this study is to assess the relationship between urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and muscle strength, and other risk factors contributing to poor muscle strength in older persons.

Methods: This was a cross-sectional study in which a total of 86 participants, both men and women, aged 65 years or above were screened for urinary 8-OHdG, and muscle strength as measured by handgrip strength.

Results: Handgrip strength was lower in participants who had history of acute or chronic disease. Urinary 8-OHdG level was negatively associated with muscle strength, and the association remained after adjusting for confounding factors.

Conclusions: Urinary 8-OHdG is associated with muscle strength. These findings may be clinically relevant as there is a possibility of controlling oxidative DNA damage by healthy behaviors related to lifestyle.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 8-Hydroxy-2'-Deoxyguanosine
  • Aged
  • Aged, 80 and over
  • Biomarkers / urine
  • Cross-Sectional Studies
  • DNA Damage
  • Deoxyguanosine / analogs & derivatives*
  • Deoxyguanosine / urine
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Hand Strength*
  • Humans
  • Japan
  • Male
  • Muscle Strength*
  • Oxidative Stress*
  • Risk Factors

Substances

  • Biomarkers
  • 8-Hydroxy-2'-Deoxyguanosine
  • Deoxyguanosine