Abstract
The use of genetic screens to define cellular pathways that regulate neurodegenerative disease proteins has emerged as a powerful strategy to identify potential therapeutic targets for these disorders. Using cross-species genetic screens, Park et al. recently identified RAS-MAPK-MSK1 as a cellular pathway that modulates levels of the polyglutamine-containing protein ATXN1 and its subsequent toxicity in SCA1.
MeSH terms
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Animals
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Drosophila melanogaster / metabolism*
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Female
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Humans
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Male
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Mitogen-Activated Protein Kinases / metabolism*
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Nerve Tissue Proteins / metabolism*
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Nerve Tissue Proteins / toxicity*
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Nuclear Proteins / metabolism*
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Nuclear Proteins / toxicity*
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Ribosomal Protein S6 Kinases, 90-kDa / metabolism*
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Spinocerebellar Ataxias / metabolism*
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Spinocerebellar Ataxias / pathology*
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ras Proteins / metabolism*
Substances
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Nerve Tissue Proteins
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Nuclear Proteins
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Ribosomal Protein S6 Kinases, 90-kDa
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Mitogen-Activated Protein Kinases
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ras Proteins