The effects of a low protein died supplemented with essential aminoacids (EAA) and keto analogues (KA) on nutritional status have been evaluated in eight chronic uremic patients. After six months of diet, no significant reduction of protidemia (changing from 6.66 +/- 0.5 g/dl to 6.61 +/- 0.8 g/dl) and albuminemia (changing from 4.13 +/- 0.4 g/dl to 3.90 +/- 0.5 g/dl) was observed. Moreover, neither body weight (changing from 70.437 +/- 8.03 kg to 69.500 +/- 8.26 kg) nor total muscular mass (changing from 25.26 +/- 3.83 kg to 25.36 +/- 5.74 kg) showed significant variations. Therefore, in our experience, low protein diet supplement with EAA and KA has not induced any deterioration of nutritional status.