Covalent small-molecule-RNA complex formation enables cellular profiling of small-molecule-RNA interactions

Angew Chem Int Ed Engl. 2013 Sep 16;52(38):10010-3. doi: 10.1002/anie.201301639. Epub 2013 Aug 1.

Abstract

Won't let you go! A strategy is described to design small molecules that react with their cellular RNA targets. This approach not only improves the activity of compounds targeting RNA in cell culture by a factor of about 2500 but also enables cell-wide profiling of its RNA targets.

Keywords: RNA; RNA recognition; bioorganic chemistry; chemical biology; nucleic acids.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Models, Molecular
  • Molecular Structure
  • Nucleic Acids / chemistry*
  • RNA / chemistry*
  • RNA / genetics

Substances

  • Nucleic Acids
  • RNA