Abstract
Target-based approaches for human African trypanosomiasis (HAT) and related parasites can be a valuable route for drug discovery for these diseases. However, care needs to be taken in selection of both the actual drug target and the chemical matter that is developed. In this article, potential criteria to aid target selection are described. Then the physiochemical properties of typical oral drugs are discussed and compared to those of known anti-parasitics.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Biological Availability
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Dosage Forms
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Drug Administration Routes
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Drug Administration Schedule
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Drug Delivery Systems*
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Drug Discovery*
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Drug Resistance
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Humans
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Structure-Activity Relationship
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Trypanocidal Agents / chemistry
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Trypanocidal Agents / pharmacokinetics*
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Trypanocidal Agents / pharmacology
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Trypanosoma brucei gambiense / drug effects*
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Trypanosoma brucei gambiense / growth & development
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Trypanosoma brucei gambiense / metabolism
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Trypanosoma brucei rhodesiense / drug effects*
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Trypanosoma brucei rhodesiense / growth & development
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Trypanosoma brucei rhodesiense / metabolism
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Trypanosomiasis, African / drug therapy*
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Trypanosomiasis, African / parasitology
Substances
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Dosage Forms
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Trypanocidal Agents