Pregnancies in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitor

Leuk Res. 2013 Oct;37(10):1216-21. doi: 10.1016/j.leukres.2013.07.020. Epub 2013 Aug 12.

Abstract

We presented our experience in chronic myeloid leukemia (CML) patients who conceived children and/or became pregnant while receiving tyrosine kinase inhibitor (TKI). Among 7 male patients, 7 pregnancies resulted in the birth of 7 healthy babies. Among 18 female patients, 8 ended in elective abortion; 3 had spontaneous abortion, and 7 carried to term, resulting in the birth of 8 healthy babies. All children have normal growth and development. All patients remain in TKI therapy and in good response. It is suggested that female patients are advised to practice adequate contraception. No special precautions apply for male patients receiving TKI.

Keywords: Chronic myeloid leukemia; Imatinib; Nilotinib; Pregnancy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / therapeutic use*
  • Child, Preschool
  • Female
  • Gonadal Hormones / blood
  • Humans
  • Infant
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / blood
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy*
  • Male
  • Middle Aged
  • Pregnancy
  • Pregnancy Outcome
  • Protein Kinase Inhibitors / administration & dosage
  • Protein Kinase Inhibitors / therapeutic use*
  • Semen Analysis
  • Treatment Outcome

Substances

  • Antineoplastic Agents
  • Gonadal Hormones
  • Protein Kinase Inhibitors