Selectively N-methylated soluble IAPP mimics as potent IAPP receptor agonists and nanomolar inhibitors of cytotoxic self-assembly of both IAPP and Aβ40

Angew Chem Int Ed Engl. 2013 Sep 23;52(39):10378-83. doi: 10.1002/anie.201302840. Epub 2013 Aug 19.
No abstract available

Keywords: IAPP receptor agonist; islet amyloid polypeptide; protein interactions; self-assembly; β-amyloid peptide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Amylin Receptor Agonists*
  • Amyloid / antagonists & inhibitors*
  • Amyloid / metabolism
  • Amyloid / ultrastructure
  • Amyloid beta-Peptides / antagonists & inhibitors
  • Amyloid beta-Peptides / metabolism
  • Amyloid beta-Peptides / ultrastructure
  • Humans
  • Islet Amyloid Polypeptide / chemistry*
  • Islet Amyloid Polypeptide / metabolism
  • Islet Amyloid Polypeptide / ultrastructure
  • Methylation
  • Molecular Sequence Data
  • Peptide Fragments / antagonists & inhibitors
  • Peptide Fragments / metabolism
  • Peptide Fragments / ultrastructure
  • Peptidomimetics / chemistry*
  • Peptidomimetics / pharmacology*
  • Receptors, Islet Amyloid Polypeptide / metabolism

Substances

  • Amylin Receptor Agonists
  • Amyloid
  • Amyloid beta-Peptides
  • Islet Amyloid Polypeptide
  • Peptide Fragments
  • Peptidomimetics
  • Receptors, Islet Amyloid Polypeptide
  • amyloid beta-protein (40-42)