Power graph compression reveals dominant relationships in genetic transcription networks

Mol Biosyst. 2013 Nov;9(11):2681-5. doi: 10.1039/c3mb70236g.

Abstract

We introduce a framework for the discovery of dominant relationship patterns in transcription networks, by compressing the network into a power graph with overlapping power nodes. Our application of this approach to the transcription networks of S. cerevisiae and E. coli, paired with GO term enrichment analysis, provides a highly informative overview of the most prominent relationships in the gene regulatory networks of these two organisms.

Publication types

  • Review

MeSH terms

  • Algorithms
  • Escherichia coli / genetics
  • Gene Expression Regulation, Bacterial
  • Gene Expression Regulation, Fungal
  • Gene Regulatory Networks*
  • Models, Biological*
  • Saccharomyces cerevisiae / genetics
  • Transcriptome*