Abstract
We report a case in which an HIV-positive man developed general malaise, skin rash and biochemical hepatitis within days of starting a nevirapine-based antiretroviral treatment regimen. At the same time, his syphilis serology proved positive. We discuss the diagnostic dilemma: was this a nevirapine hypersensitivity reaction, secondary syphilis or both?
Keywords:
AIDS; HIV; antiretroviral toxicity; diagnosis; nevirapine; syphilis.
MeSH terms
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Adult
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Anti-HIV Agents / adverse effects*
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Anti-HIV Agents / therapeutic use
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CD4 Lymphocyte Count
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Diagnosis, Differential
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Exanthema / chemically induced*
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HIV Infections / drug therapy*
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Hepatitis / complications
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Hepatitis / drug therapy
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Humans
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Hypersensitivity / complications
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Hypersensitivity / drug therapy
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Kenya
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Nevirapine / adverse effects*
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Nevirapine / therapeutic use
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Syphilis / diagnosis*
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Syphilis / drug therapy
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Treatment Outcome
Substances
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Anti-HIV Agents
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Nevirapine