A bisphosphonate tweezers and clickable PEGylated PAMAM dendrons for the preparation of functional iron oxide nanoparticles displaying renal and hepatobiliary elimination

Chem Commun (Camb). 2013 Oct 14;49(80):9158-60. doi: 10.1039/c3cc43161d. Epub 2013 Aug 29.

Abstract

The functionalization of superparamagnetic iron oxide nanoparticles (SPION) with PEGylated PAMAM dendrons through a bisphosphonate tweezers yielded 15 and 30 nm dendritic nano-objects stable in physiological media and showing both renal and hepatobiliary elimination.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dendrimers / chemistry*
  • Dendrimers / metabolism
  • Diphosphonates / chemistry*
  • Ferric Compounds / chemistry*
  • Kidney / metabolism
  • Kinetics
  • Liver / metabolism
  • Magnetite Nanoparticles / chemistry*
  • Mice
  • Polyethylene Glycols / chemistry*
  • Spleen / metabolism

Substances

  • Dendrimers
  • Diphosphonates
  • Ferric Compounds
  • Magnetite Nanoparticles
  • PAMAM Starburst
  • ferric oxide
  • Polyethylene Glycols