Association of nicotinamide-N-methyltransferase (NNMT) gene rs694539 variant with bipolar disorder

Gene. 2013 Dec 15;532(2):272-5. doi: 10.1016/j.gene.2013.08.077. Epub 2013 Sep 1.

Abstract

Here we report the association of the rs694539 variant of nicotinamide-N-methyltransferase gene with bipolar disorder in a case-control study of 95 bipolar disorder patients and 201 healthy controls (χ(2)=13.382, P=0.001). With the polymerase chain reaction restriction fragment length polymorphism method we developed we were able to show the association for the first time. This new finding may provide evidence to understand the mechanism of the disease.

Keywords: Association; Bipolar disorder; CI; Gender; HWE; Hardy–Weinberg equilibrium; MTHFR; NNMT; NNMT gene; OR; PAGE; PCR; PCR-RFLP; Turkey; confidence interval; methylenetetrahyrofolate reductase; nicotinamide-N-methyltransferase; odds ratio; polyacrylamide gel electrophoresis; polymerase chain reaction; polymerase chain reaction-restriction fragment length polymorphism; rs694539.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Bipolar Disorder / enzymology
  • Bipolar Disorder / genetics*
  • Case-Control Studies
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Middle Aged
  • Nicotinamide N-Methyltransferase / genetics*
  • Odds Ratio
  • Polymorphism, Single Nucleotide*
  • Sequence Analysis, DNA
  • Young Adult

Substances

  • NNMT protein, human
  • Nicotinamide N-Methyltransferase