Researches on antiinflammatory agents. Studies on some new 3-(pyrazol-5-yl)-1,2,3-benzotriazin-4(3H)-ones and -quinazolin-4(3H)-ones

Farmaco. 1990 Apr;45(4):391-8.

Abstract

Following our research on analgesic and antiinflammatory active compounds containing the pyrazole nucleus, a number of 3-(pyrazol-5-yl)-1,2,3-benzotriazin-4(3H)-ones and quinazolin-4(3H)-ones was synthetized and tested. The results of tests for analgesic, antiexudative and antioedema activities, as well as for induction of lesion in the gastric mucosa, are reported and discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
  • Anti-Inflammatory Agents, Non-Steroidal / toxicity
  • Behavior, Animal / drug effects
  • Chemical Phenomena
  • Chemistry
  • Exudates and Transudates / drug effects
  • Lethal Dose 50
  • Male
  • Mice
  • Pyrazoles / chemical synthesis*
  • Pyrazoles / pharmacology
  • Pyrazoles / toxicity
  • Quinazolines / chemical synthesis*
  • Quinazolines / pharmacology
  • Quinazolines / toxicity
  • Rats
  • Rats, Inbred Strains
  • Stomach Ulcer / chemically induced
  • Stomach Ulcer / physiopathology
  • Structure-Activity Relationship
  • Triazines / chemical synthesis*
  • Triazines / pharmacology
  • Triazines / toxicity

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Pyrazoles
  • Quinazolines
  • Triazines