Abstract
Induced pluripotent stem cells (iPSCs) could be generated by a single gene Oct4 and chemical compounds, in which exogenous expression of Oct4 was indispensable for reprogramming. Recent advances in chemical-mediated cellular reprogramming suggest that small molecules alone (i.e. without Yamanaka factors) can successfully establish iPSCs from mouse somatic cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cellular Reprogramming / drug effects
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Colforsin / pharmacology*
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Embryo, Mammalian / cytology
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Fibroblasts / cytology
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Fibroblasts / drug effects
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Fibroblasts / metabolism
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Green Fluorescent Proteins / metabolism
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Humans
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Induced Pluripotent Stem Cells / cytology*
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Induced Pluripotent Stem Cells / drug effects
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Induced Pluripotent Stem Cells / metabolism*
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Mice
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Octamer Transcription Factor-3 / metabolism
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Transgenes / genetics*
Substances
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Octamer Transcription Factor-3
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Green Fluorescent Proteins
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Colforsin