Programmable hydrogels for the controlled release of therapeutic nucleic acid aptamers via reversible DNA hybridization

Xiaolong Zhang; Mark R Battig; Yong Wang

doi:10.1039/c3cc45594g

Programmable hydrogels for the controlled release of therapeutic nucleic acid aptamers via reversible DNA hybridization

Chem Commun (Camb). 2013 Oct 25;49(83):9600-2. doi: 10.1039/c3cc45594g.

Authors

Xiaolong Zhang¹, Mark R Battig, Yong Wang

Affiliation

¹ Department of Bioengineering, College of Engineering, The Pennsylvania State University, University Park, PA 16802-6804, USA. yxwbio@engr.psu.edu.

PMID: 24018965
DOI: 10.1039/c3cc45594g

Abstract

Reversible DNA hybridization can be used as a new mechanism to control the sustained and triggered release of therapeutic oligonucleotides from hydrogels.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Aptamers, Nucleotide / administration & dosage*
Aptamers, Nucleotide / chemistry
DNA / chemistry
Delayed-Action Preparations / chemistry*
Hydrogels / chemistry*
Nucleic Acid Hybridization

Substances

Aptamers, Nucleotide
Delayed-Action Preparations
Hydrogels
DNA