Abstract
We investigated the pol genotype in two phylogenetically and epidemiologically linked partners, who were both experiencing persistent low-level viremia during antiretroviral therapy. In one partner we identified a new residue insertion between codon 248 and 249 of the HIV-1 RNA reverse transcriptase (RT) coding region (HXB2 numbering). We then investigated the potential impact of identified mutations in RT and antiretroviral binding affinity using a novel computational approach.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amino Acid Sequence
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Anti-Retroviral Agents / therapeutic use*
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HIV Infections / drug therapy*
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HIV Infections / virology*
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HIV Reverse Transcriptase / genetics*
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HIV-1 / genetics*
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HIV-1 / isolation & purification*
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Humans
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Male
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Models, Molecular
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Molecular Sequence Data
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Mutagenesis, Insertional*
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Protein Conformation
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Viremia
Substances
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Anti-Retroviral Agents
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reverse transcriptase, Human immunodeficiency virus 1
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HIV Reverse Transcriptase