Association of the GDNF gene with depression and heroin dependence, but not schizophrenia, in a Chinese population

Psychiatry Res. 2013 Dec 30;210(3):1296-8. doi: 10.1016/j.psychres.2013.08.025. Epub 2013 Sep 7.

Abstract

The association of seven GDNF tag SNPs with depression, heroin dependence (HD) and schizophrenia was evaluated in Chinese. An increased risk of HD and depression was associated with rs2910709 T/T genotype and rs884344 C allele, respectively, suggesting GDNF is a novel susceptibility gene for depression and HD.

Keywords: Depression; Glial cell line-derived neurotrophic factor; Heroin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Asian People / genetics*
  • Asian People / psychology
  • Case-Control Studies
  • Depression / ethnology
  • Depression / genetics*
  • Depression / psychology
  • Depressive Disorder / genetics
  • Genetic Predisposition to Disease / ethnology
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Glial Cell Line-Derived Neurotrophic Factor / genetics*
  • Heroin Dependence / ethnology
  • Heroin Dependence / genetics*
  • Heroin Dependence / psychology
  • Humans
  • Polymorphism, Genetic*
  • Polymorphism, Single Nucleotide
  • Schizophrenia / genetics
  • Schizophrenic Psychology

Substances

  • Glial Cell Line-Derived Neurotrophic Factor