Postdate pregnancy: changes of placental/membranes 11β-hydroxysteroid dehydrogenase mRNA and activity

Placenta. 2013 Nov;34(11):1102-4. doi: 10.1016/j.placenta.2013.08.011. Epub 2013 Sep 4.

Abstract

11β-Hydroxysteroid dehydrogenase 1 and 2 (11β-HSD1 and 11β-HSD2) are involved in the complex mechanism of human parturition. The present study examined mRNA expression and activity of membrane 11β-HSD1 and placental 11β-HSD2 in postdate pregnancies according to response of labor induction. In comparison to postdate women who had spontaneous delivery or after induction the non-responders showed significantly low c and high 11β-HSD2 expression and activity These data suggest that disrupted expression and activity of 11β-HSDs may occur in some postdate pregnancies.

Keywords: 11Beta-HSD enzymes; Labor induction; Postdate.

MeSH terms

  • 11-beta-Hydroxysteroid Dehydrogenase Type 1 / genetics
  • 11-beta-Hydroxysteroid Dehydrogenase Type 1 / metabolism*
  • 11-beta-Hydroxysteroid Dehydrogenase Type 2 / biosynthesis
  • 11-beta-Hydroxysteroid Dehydrogenase Type 2 / genetics
  • 11-beta-Hydroxysteroid Dehydrogenase Type 2 / metabolism*
  • Adult
  • Delivery, Obstetric
  • Dinoprostone
  • Down-Regulation / drug effects
  • Drug Resistance
  • Extraembryonic Membranes / drug effects
  • Extraembryonic Membranes / enzymology
  • Extraembryonic Membranes / metabolism*
  • Female
  • Gene Expression Regulation, Developmental* / drug effects
  • Humans
  • Labor, Induced
  • Oxytocics
  • Placenta / drug effects
  • Placenta / enzymology
  • Placenta / metabolism*
  • Pregnancy
  • Pregnancy, Prolonged / enzymology
  • Pregnancy, Prolonged / metabolism*
  • RNA, Messenger / metabolism*
  • Reproducibility of Results
  • Up-Regulation / drug effects

Substances

  • Oxytocics
  • RNA, Messenger
  • 11-beta-Hydroxysteroid Dehydrogenase Type 1
  • 11-beta-Hydroxysteroid Dehydrogenase Type 2
  • HSD11B1 protein, human
  • HSD11B2 protein, human
  • Dinoprostone