Surface glycoproteins of an African henipavirus induce syncytium formation in a cell line derived from an African fruit bat, Hypsignathus monstrosus

J Virol. 2013 Dec;87(24):13889-91. doi: 10.1128/JVI.02458-13. Epub 2013 Sep 25.

Abstract

Serological screening and detection of genomic RNA indicates that members of the genus Henipavirus are present not only in Southeast Asia but also in African fruit bats. We demonstrate that the surface glycoproteins F and G of an African henipavirus (M74) induce syncytium formation in a kidney cell line derived from an African fruit bat, Hypsignathus monstrosus. Despite a less broad cell tropism, the M74 glycoproteins show functional similarities to glycoproteins of Nipah virus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Africa
  • Animals
  • Asia, Southeastern
  • Cell Line
  • Chiroptera / virology*
  • Giant Cells / virology*
  • Henipavirus / genetics
  • Henipavirus / isolation & purification*
  • Henipavirus / metabolism*
  • Henipavirus Infections / veterinary*
  • Henipavirus Infections / virology
  • Viral Envelope Proteins / genetics
  • Viral Envelope Proteins / metabolism*

Substances

  • Viral Envelope Proteins