We have recently been the first to demonstrate that interleukin (IL)-27 protects against the emergence and progression of autochthonous tumors. Accumulating evidence suggests that IL-27 might be uniquely well positioned to amplify beneficial TH1 anticancer immune responses while suppressing the unwanted accumulation of regulatory T cells.
Keywords: 3-methylcholanthrene; Tregs; interferon γ; interleukin-27; polyomavirus middle T antigen (PyMT)-induced mammary carcinoma.