Regenerative activity of 2-(1'-hydroxy-4'-isopropenyl-1'-methylcyclohexyl-2'-thio) methyl ethanoate gel

I V Akulina; N A Pozdeeva; I A Frolychev; A O Shikhanov; V N Ovchinnikova

doi:10.1007/s10517-013-2176-3

Regenerative activity of 2-(1'-hydroxy-4'-isopropenyl-1'-methylcyclohexyl-2'-thio) methyl ethanoate gel

Bull Exp Biol Med. 2013 Aug;155(4):454-7. doi: 10.1007/s10517-013-2176-3.

Authors

I V Akulina¹, N A Pozdeeva, I A Frolychev, A O Shikhanov, V N Ovchinnikova

Affiliation

¹ Territorial Organ of the Federal Service on Surveillance in Healthcare and Social Development of the Chuvash Republic; S. N. Fedorov Intersectoral Research and Technology Complex " Eye Microsurgery", Cheboksary branch, Ministry of Health of the Russian Federation, Russia. ir.ak-na@mail.ru.

PMID: 24143366
DOI: 10.1007/s10517-013-2176-3

Abstract

We studied regenerative activity of a sulfur-containing menthane terpenoid (2-(1'-hydroxy-4'-isopropenyl-1'-methylcyclohexyl-2'-thio) methyl ethanoate) in the form of gels with different concentrations in experimental superficial non-penetrating corneal wound. The examined compound significantly increased the regenerative activity by accelerating the onset and completion of epithelialization. The use of 2% and 3% gel ensured finer scarring.

MeSH terms

Animals
Cornea / drug effects*
Cornea / physiopathology
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Eye Injuries / drug therapy*
Eye Injuries / physiopathology
Female
Male
Monoterpenes / administration & dosage*
Rabbits
Re-Epithelialization / drug effects*
Regenerative Medicine
Thioglycolates / administration & dosage*

Substances

Monoterpenes
Thioglycolates
methyl 2-(1'-hydroxy-4'-isopropenyl-1'-methylcyclohexyl-2'-thio)ethanoate