Genotoxic and mutagenic effects of diflubenzuron, an insect growth regulator, on mice

J Toxicol Environ Health A. 2013;76(17):1003-6. doi: 10.1080/15287394.2013.830585.

Abstract

This study assessed the genotoxic and mutagenic potential of diflubenzuron (DFB) insecticide in mice. Mice were divided into five groups: group I: negative control; group II: positive control; group III: 0.3 mg/kg of DFB; group IV: 1 mg/kg of DFB; group V: 3 mg/kg DFB. Peripheral blood was collected for the comet assay and the micronucleus (MN) test. DFB increased incidence of comet formation at all doses tested. A rise in the frequency of MN in mouse peripheral blood was observed 24, 48, and 72 h postexposure at all doses tested. Data demonstrate that DFB exerts genotoxic and mutagenic effects in a dose-dependent manner.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Comet Assay
  • Diflubenzuron / toxicity*
  • Dose-Response Relationship, Drug
  • Insecticides / toxicity*
  • Male
  • Mice
  • Micronucleus Tests
  • Mutagens / toxicity*

Substances

  • Insecticides
  • Mutagens
  • Diflubenzuron