In vitro and in vivo imaging application of a 1,8-naphthalimide-derived Zn(2+) fluorescent sensor with nuclear envelope penetrability

Changli Zhang; Zhipeng Liu; Yunling Li; Weijiang He; Xiang Gao; Zijian Guo

doi:10.1039/c3cc46862c

In vitro and in vivo imaging application of a 1,8-naphthalimide-derived Zn(2+) fluorescent sensor with nuclear envelope penetrability

Chem Commun (Camb). 2013 Dec 18;49(97):11430-2. doi: 10.1039/c3cc46862c.

Authors

Changli Zhang¹, Zhipeng Liu, Yunling Li, Weijiang He, Xiang Gao, Zijian Guo

Affiliation

¹ State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China. heweij69@nju.edu.cn zguo@nju.edu.cn.

PMID: 24169806
DOI: 10.1039/c3cc46862c

Abstract

A newly developed fluorescent sensor, , shows a specific turn-on response to Zn(2+) and can be excited by visible light. The in situ nuclear Zn(2+) imaging in HeLa and HepG2 cells reveals the nuclear envelope penetrability of the sensor. The specific sensor location in a zebrafish larva was also demonstrated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkynes / chemistry
Animals
Anthracenes / chemistry
Fluorescent Dyes / chemistry*
HeLa Cells
Hep G2 Cells
Humans
Larva / metabolism
Light
Microscopy, Confocal
Nuclear Envelope / chemistry
Nuclear Envelope / metabolism*
Zebrafish / growth & development
Zinc / chemistry*

Substances

Alkynes
Anthracenes
Fluorescent Dyes
9,10-bis(phenylethynyl)anthracene
Zinc