Dynamics of cytomegalovirus populations harbouring mutations in genes UL54 and UL97 in a haematopoietic stem cell transplant recipient

J Clin Virol. 2013 Dec;58(4):733-6. doi: 10.1016/j.jcv.2013.10.007. Epub 2013 Oct 16.

Abstract

We characterised by pyrosequencing, the dynamics of cytomegalovirus populations harbouring mutations A594V in gene UL97 and A834P and Q578H in gene UL54 in a haematopoietic stem cell transplant recipient. Unexpected re-emergence of A594V and decrease of A834P under CMX001 were shown to depend on both the selection pressure exerted by the antiviral treatments and the immune response.

Keywords: CDV; CMV; CTSQ; Cytomegalovirus; FOS; GCV; HSCT; Kinetics; Mutation; PSQ; Resistance; Stem cell transplantation; cidofovir; cytomegalovirus; direct dideoxy chain termination sequencing; foscarnet; ganciclovir; haematopoietic stem cell transplant; pyrosequencing; vGCV; valganciclovir.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antiviral Agents / therapeutic use
  • Cytomegalovirus / genetics*
  • Cytomegalovirus Infections / drug therapy
  • Cytomegalovirus Infections / virology*
  • Drug Resistance, Viral / genetics
  • Female
  • Genes, Viral
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Mutation*
  • Young Adult

Substances

  • Antiviral Agents