We characterised by pyrosequencing, the dynamics of cytomegalovirus populations harbouring mutations A594V in gene UL97 and A834P and Q578H in gene UL54 in a haematopoietic stem cell transplant recipient. Unexpected re-emergence of A594V and decrease of A834P under CMX001 were shown to depend on both the selection pressure exerted by the antiviral treatments and the immune response.
Keywords: CDV; CMV; CTSQ; Cytomegalovirus; FOS; GCV; HSCT; Kinetics; Mutation; PSQ; Resistance; Stem cell transplantation; cidofovir; cytomegalovirus; direct dideoxy chain termination sequencing; foscarnet; ganciclovir; haematopoietic stem cell transplant; pyrosequencing; vGCV; valganciclovir.
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