Urea transporter inhibitors: en route to new diuretics

Chem Biol. 2013 Oct 24;20(10):1201-2. doi: 10.1016/j.chembiol.2013.10.003.

Abstract

A selective urea transporter UT-A1 inhibitor would be a novel type of diuretic, likely with less undesirable side effects than conventional diuretics, because it acts on the last portion of the nephron. In this issue of Chemistry & Biology, Esteva-Font and colleagues develop such an inhibitor by using a clever high-throughput screening assay and document its selectivity.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Drug Evaluation, Preclinical*
  • Membrane Transport Proteins / metabolism*
  • Small Molecule Libraries / analysis*
  • Small Molecule Libraries / pharmacology*
  • Urea Transporters

Substances

  • Membrane Transport Proteins
  • Small Molecule Libraries