Psychosis with obsessive-compulsive symptoms in tuberous sclerosis

J Clin Neurosci. 2014 May;21(5):867-9. doi: 10.1016/j.jocn.2013.08.005. Epub 2013 Aug 26.

Abstract

We present a case of tuberous sclerosis complex (TSC) diagnosed in adulthood in a man initially referred for specialist neuropsychiatric assessment with psychosis and obsessive-compulsive symptoms (OCS) on a background of epilepsy and intellectual disability. To our knowledge, this is the first reported patient with TSC featuring both psychosis and OCS. This patient highlights the importance of comprehensive re-evaluation of atypical presentations of intellectual disability, epilepsy and associated neuropsychiatric symptoms, even in adulthood. This is particularly relevant in the context of significant advances in genetics, neuroscience, imaging and treatments for heritable neurogenetic disorders.

Keywords: Epilepsy; Neuropsychiatry; Obsessive compulsive disorder; Psychosis; Tuberous sclerosis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Humans
  • Male
  • Obsessive-Compulsive Disorder / complications*
  • Obsessive-Compulsive Disorder / diagnosis*
  • Obsessive-Compulsive Disorder / psychology
  • Psychotic Disorders / complications*
  • Psychotic Disorders / diagnosis*
  • Psychotic Disorders / psychology
  • Tuberous Sclerosis / complications*
  • Tuberous Sclerosis / diagnosis*
  • Tuberous Sclerosis / psychology