TLR5 stops commensals in their tracks

Meghan A Koch; Gregory M Barton

doi:10.1016/j.chom.2013.10.015

TLR5 stops commensals in their tracks

Cell Host Microbe. 2013 Nov 13;14(5):488-90. doi: 10.1016/j.chom.2013.10.015.

Authors

Meghan A Koch¹, Gregory M Barton

Affiliation

¹ Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3200, USA.

PMID: 24237694
DOI: 10.1016/j.chom.2013.10.015

Abstract

IgA antibodies help maintain intestinal immune homeostasis with resident commensal species; however, the precise mechanisms regulating IgA induction and the epitopes recognized by these antibodies remain incompletely understood. In this issue of Cell Host & Microbe, Tyler et al. (2013) demonstrate that TLR5-dependent induction of anti-flagellin antibodies prevents commensal association with the intestinal mucosa by limiting bacterial motility.

Publication types

Comment

MeSH terms

Animals
Flagellin / immunology*
Gastrointestinal Tract / immunology*
Gastrointestinal Tract / microbiology*
Immunity, Mucosal*
Locomotion*
Microbiota / immunology*

Substances

Flagellin