Although perceived discrimination has been associated with depressive symptoms among Hispanic adults, not all individuals who report discrimination will report elevated levels of depression. This study examined whether acculturation and religious coping would moderate the association between past-year perceived discrimination and depressive symptoms in a sample of 247 Mexican-American post-secondary vocational students (59.6 % males; mean age = 26.81). Results from hierarchical regression analyses indicated that perceived discrimination, positive religious coping, and negative religious coping were significantly associated with depressive symptoms. Further analyses indicated that positive religious coping moderated the perceived discrimination-depressive symptoms association. Students reporting using positive religious coping were protected from experiencing heightened levels of depressive symptoms when faced with discrimination. Acculturation was not directly associated with depressive symptoms nor did it function as a moderator. The salutary influences of positive religious coping for Mexican-American students are discussed. Study limitations and future directions for research are also discussed.