A convenient method to produce [(14) C]carbon monoxide and its application to the radiosynthesis of [carboxyl-(14) C]celivarone, [carboxyl-(14) C]SSR149744

J Labelled Comp Radiopharm. 2013 Feb;56(2):36-41. doi: 10.1002/jlcr.3009. Epub 2013 Jan 22.

Abstract

[carboxyl-(14) C]Celivarone was synthesised from barium [(14) C]carbonate with overall radiochemical yields in the range 49-53%. The synthetic route involves [(14) C]carbonylation methodology, which both decreased the number of synthetic steps and increased the yields obtained from previous synthetic routes.

Keywords: [14C]carbonylation; [carboxyl-14C]celivarone; antiarrhythmic; lithium [14C]formate.

MeSH terms

  • Anti-Arrhythmia Agents / chemical synthesis*
  • Barium
  • Benzofurans / chemical synthesis*
  • Carbon Monoxide / chemical synthesis*
  • Carbon Radioisotopes / chemistry*
  • Carbonates / chemical synthesis
  • Isotope Labeling / methods
  • Radiopharmaceuticals / chemical synthesis*

Substances

  • Anti-Arrhythmia Agents
  • Benzofurans
  • Carbon Radioisotopes
  • Carbonates
  • Radiopharmaceuticals
  • Barium
  • barium carbonate
  • Carbon Monoxide
  • celivarone