Nitrite activation to nitric oxide via one-fold protonation of iron(II)-O,O-nitrito complex: relevance to the nitrite reductase activity of deoxyhemoglobin and deoxyhemerythrin

Chih-Chin Tsou; Wan-Lin Yang; Wen-Feng Liaw

doi:10.1021/ja4105864

Nitrite activation to nitric oxide via one-fold protonation of iron(II)-O,O-nitrito complex: relevance to the nitrite reductase activity of deoxyhemoglobin and deoxyhemerythrin

J Am Chem Soc. 2013 Dec 18;135(50):18758-61. doi: 10.1021/ja4105864. Epub 2013 Dec 5.

Authors

Chih-Chin Tsou¹, Wan-Lin Yang, Wen-Feng Liaw

Affiliation

¹ Department of Chemistry and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University , Hsinchu, 30013, Taiwan.

PMID: 24289743
DOI: 10.1021/ja4105864

Abstract

The reversible transformations [(Bim)3Fe(κ(2)-O2N)][BF4] (3) <-> [(Bim)3Fe(NO)(κ(1)-ONO)][BF4]2 (4) were demonstrated and characterized. Transformation of O,O-nitrito-containing complex 3 into [(Bim)3Fe(μ-O)(μ-OAc)Fe(Bim)3](3+) (5) along with the release of NO and H2O triggered by 1 equiv of AcOH implicates that nitrite-to-nitric oxide conversion occurs, in contrast to two protons needed to trigger nitrite reduction producing NO observed in the protonation of [Fe(II)-nitro] complexes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Ferrous Compounds / chemistry*
Hemerythrin / chemistry*
Hemoglobins / chemistry*
Nitric Oxide / chemistry*
Nitrite Reductases / chemistry*
Nitrites / chemistry*
Spectrum Analysis / methods

Substances

Ferrous Compounds
Hemerythrin
Hemoglobins
Nitrites
deoxyhemerythrin
Nitric Oxide
deoxyhemoglobin
Nitrite Reductases