Timed up and go, cognitive, and quality-of-life correlates in Parkinson's disease

Arch Phys Med Rehabil. 2014 Apr;95(4):649-55. doi: 10.1016/j.apmr.2013.10.031. Epub 2013 Nov 27.

Abstract

Objective: To examine the relationship between Timed Up and Go (TUG) performance, verbal executive function (EF) performance, and quality-of-life (QOL) measures in Parkinson's disease (PD).

Design: Cross-sectional.

Setting: Sixteen movement disorder centers from across the United States.

Participants: Patients with PD (N=1964).

Interventions: Not applicable.

Main outcome measures: TUG test, immediate and delayed 5-word recall, verbal fluency, PD QOL Questionnaire.

Results: TUG performance and verbal EF performance were significantly associated with, and predictors of, QOL measures, having the greatest association and predictability with the mobility domain of the QOL measures.

Conclusions: The TUG test and verbal EF tests have QOL correlates, making the combined evaluation of mobility, cognitive, and QOL decline a potential examination tool to evaluate the sequelae of PD.

Keywords: Cognition; Parkinson's disease; Quality of life; Rehabilitation.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cross-Sectional Studies
  • Disability Evaluation*
  • Executive Function / physiology
  • Female
  • Humans
  • Male
  • Mental Recall / physiology
  • Middle Aged
  • Parkinson Disease / physiopathology*
  • Parkinson Disease / psychology*
  • Quality of Life*
  • Regression Analysis
  • Surveys and Questionnaires
  • Verbal Learning / physiology