Abstract
Dehydroindicolactone, a novel linear furanocoumarin with an 8-substituted side chain carrying a 5-member ring lactone, showed spasmolytic activity in a number of smooth muscle preparations. The spasmolytic activity seems to lie in its ability to block the dihydropyridine-sensitive calcium channel.
MeSH terms
-
Animals
-
Blood Pressure / drug effects
-
Calcium / metabolism
-
Coumarins / pharmacology*
-
Female
-
Guinea Pigs
-
In Vitro Techniques
-
Ion Channels / drug effects
-
Lactones / pharmacology*
-
Male
-
Muscle Contraction / drug effects*
-
Muscle Relaxation / drug effects*
-
Muscle, Smooth / drug effects*
-
Myocardial Contraction / drug effects
-
Parasympatholytics*
-
Rabbits
-
Rats
-
Uterine Contraction / drug effects
-
Vas Deferens / drug effects
Substances
-
Coumarins
-
Ion Channels
-
Lactones
-
Parasympatholytics
-
dehydroindicolactone
-
Calcium