Gene-environment interactions in heavy metal and pesticide carcinogenesis

Mutat Res Genet Toxicol Environ Mutagen. 2014 Jan 15:760:1-9. doi: 10.1016/j.mrgentox.2013.11.002. Epub 2013 Dec 3.

Abstract

Cancer is a complex disease involving a sequence of gene-environment interactions. Lifestyle, genetics, dietary factors, and environmental pollutants can increase the risk of cancer. Gene-environment interactions have been studied by a candidate-gene approach focusing on metabolism, DNA repair, and apoptosis. Here, we review the influence of gene-environment interactions in carcinogenesis, with emphasis on heavy metal and pesticide exposures.

Keywords: Environment; Gene; Heavy metals; Pesticides; Polymorphism.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carcinogenesis / chemically induced*
  • Carcinogenesis / genetics
  • Environmental Exposure / adverse effects
  • Environmental Pollutants / poisoning*
  • Gene-Environment Interaction*
  • Genetic Predisposition to Disease / genetics
  • Heavy Metal Poisoning*
  • Humans
  • Neoplasms / etiology
  • Neoplasms / genetics
  • Pesticides / poisoning*

Substances

  • Environmental Pollutants
  • Pesticides